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KMID : 0378019720150050118
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New Medical Journal
1972 Volume.15 No. 5 p.118 ~ p.121
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ACTH-induced Change in Adrenal Ascorbic Acid Content of Immature Rats under the Influence of Panax Ginseng
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Abstract
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A study was planned to clarify the influence of ginseng upon stress mechanism in immature rats and to compare the findings with those observed in mature rats.
Two hundred eighty immature male rats (body weight: 35-40 gm) were divided equally into the ginseng control, the saline control, the ginseng-ACTH and the saline-ACTH groups, according to the drugs they received. For 45 days the ginseng control and the ginseng-ACTH groups received 0. 5 ml/100 gm body weight of ginseng alcohol extract solution (4 mg of extract dissolved in 1 ml saline) while the saline-control and the saline-ACTH groups received the same amount of saline. Ten animals at a time of the ginseng-ACTH and the saline-ACTH groups received one dose of 0. 01 unit ACTH once on the 1st, 5th, 10th, 15th, 25th, 35th or on the 45th experimental day 1 hr after ginseng or saline administration. After another hour, these animals and 10 animals each of the ginseng control and the saline control group animals had their adrenal glands removed under deep anesthesia. Adrenal ascorbic acid content was measured colorimetrically utilizing the reduction of 2, 6-dichloro￢phenol-indophenol sodium.
Following results were obtained:
1. The adrenal ascorbic acid content of the ginseng control group did not differ significantly from that of the saline control group throughout the experimental period.
2. The adrenal ascorbic acid content of the ginseng-ACTH group was significantly less than that of the ginseng control group but significantly higher than that of the saline-ACTH group through the experiment.
From the above results, it is inferred that the ginseng has no influence upon the adrenal ascorbic acid content of immature rats under normal condition, but that the drug does mitigate a fall in the ascorbic acid content under the influence of ACTH. The results are found to be in good accordance with those observed in mature rats.
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